Publications archive

Zaldívar-Espinal KM, Peña AS, Serrano-Vela JI.

EMPODERAMIENTO Y CALIDAD DE VIDA EN PERSONAS CELÍACAS ADULTAS DE EL SALVADOR

Acta Gastroenterol Latinoam. 2022 Mar 30;52(1):86-95. DOI:https://doi.org/10.52787/agl.v52i1.162
Anke Ruettger, Jens Feige, Peter Slickers, Evelyn Schubert, Servaas. Morré, Yvonne Pannekoek, Björn Herrmann, Henry J.C. de Vries, Ralf Ehricht, Konrad Sachse

Genotyping of Chlamydia trachomatis strains from culture and clinical samples using an ompA-based DNA microarray assay

Molecular and Cellular Probes 25 (2011) 19-27
Coutinho, Peña, Morré

A multidisciplinary approach to the study of Chlamydia trachomatis infections Female urogenital and male anorectal infections

ISBN-10: 90-90212217-5
Laine, Farré, Crusius, Winkelhoff, Peña

A non-invasive sampling method to study cytokine gene Polymorphisms

J Periodontol – August 2000
Muhammed Hadithi

On diagnostic tools in coeliac disease and its complicated forms

ISBN: 9789086591961
Amado S. Peña, MD, PhD, FRCP* and Cisca Wijmenga, PhD

Genetic Factors Underlying Gluten-Sensitive Enteropathy

Current Allergy and Asthma Reports 2001, 1:526–533 Current Science Inc. ISSN 1529–7322
A.S. Peña MD, PhD, FRCP

Genetic factors determining the host response to Helicobacter pylori

World J Gastroentero, 2000;6(5):624-625
I. POLANCO, M. 1. MEARIN, J. LARRAURI, I. BIEMOND, A. WIPKINK-BAKKER, and A. S. PENA

Effect of Gluten Supplementation in Healthy Siblings of Children With Celiac Disease

GASTROENTEROLOGY 1987;D~:678-81
A.S. Peña, J.B.A. Crusius, and S.G.M. Meuwissen

Genetic markers in ulcerative colitis. Why are the results different?

Eur J Gastroenterol Hepatol. 1999;11:405-7.
S.A. Morré

Lymphogranuloma venereum variant L2b-specific polymerase chain reaction: insertion used to close an epidemiological gap

2011 European Society of Clinical Microbiology and Infectious Diseases, CMI, 17, 1727–1730
A.S. Peña

Clinicas de gastroenterología

ISBN 978-607-8045-33-4
Bouma, Xia, Crusius, Bioque, Koutrobakis, von Blomberg, Meuwissen, Peña

Distribution of four polymorphisms in the tumour necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD)

Clin. Ecp. Immunol 1996: 103: 391-396
Bouma, Oudkerk, Pool, Crusius, Schreuders, Hellemans, Mejier, Kostense, Gipharts, Meuwissen, Peña.

Evidence for genetic heterogen in inflammatory bowel disease (IBD): HLA genes in the predisposition to suffer from ulcerative colitis (UC) and Crohn’s disease (CD)

Clin Exp. Immunol 1997: 109:175-179
A.S. Peña

El continuo aumento de la enfermedad crónica inflamatoria intestinal en España

Anales de medicina interna 0212-7199 (2000) 17:6 pp 283-284
Walvoort and A.S. Peña

CROHN’S DISEASE: A CHALLENGE TO THE ENTITY CONCEPT

Elsevier Science Publishers
Peña, Laine, Crusius, Morré, Van der velden, Lessmann, Van der Palen, Van Winkelhoff, Loss

Genetics and Genomics: Implications for clinical practice

IBD
A.S. Peña

¿Algo más que la dieta sin gluten?

GH Continuada Noviembre-Diciembre 2006 Vol 5 Nº6
Lal JA, Schulte in den Bäumen T, Morré SA, Brand A.

Public Health and valorization of genome-based technologies: a new model.

J Transl Med 2011;9(1):207. doi:10.1186/1479-5876-9-207
Bongaerts M, van de Bovenkamp JHB, Morré SA, Manders MELM and Heddema ER.

Evaluation of the Siemens VERSANT(r) CT/GC DNA 1.0 Assay (kPCR) for detection of Chlamydia trachomatis and Neisseria gonorrhoeae.

Journal of Microbiological Methods 2011; 87(2):139-42.
Peters RPH, Verweij SP, Nijsten N, Ouburg S, Mutsaers J, Jansen CL, van Leeuwen AP, Morré SA.

Evaluation of sexual history-based screening of anatomic sites for Chlamydia trachomatis and Neisseria gonorrhoeae infection in men having sex with men in routine practice.

BMC Infect Dis. 2011;11:203. (pp 1-7)
Christerson L, de Vries HJC, Klint M, Herrmann B, Morré SA.

Multilocus Sequence Typing of Urogenital Chlamydia trachomatis from Patients with Different Degrees of Clinical Symptoms.

Sex Transm Dis 2011; 38(6):490-494
Verweij S, Catsburg A, Ouburg S, Lombardi A, Heijmans R, Dutly F, Frei R, Morré SA, Goldenberger D.

Lymphogranuloma venereum variant L2b-specific polymerase chain reaction: insertion used to close an epidemiological gap.

Clin Microbiol Infect 2011;17(11):1727-30.
Sanders MS, van Well GThJ, Ouburg S, Morré SA, van Furth AM.

Genetic variation of innate immune response genes in invasive pneumococcal and meningococcal disease applied to the pathogenesis of meningitis.

Genes Immun 2011;12(5):321-334
Peters RPH, Nijsten N, Mutsaers J, Jansen CL, Morré SA, van Leeuwen AP

Screening of oropharynx and anorectum increases prevalence of Chlamydia trachomatis and Neisseria gonorrhoea infection in female STD clinic visitors.

Sex Transm Dis 2011; 38:783-787.
Smelov V, van Moorselaar J, Startsev V, Smelova N, Grigorovich E, Meijer CJLM, Morré SA.

No high-risk human papillomavirus infection in prostate cancer tissues.

Scand J Infect Dis 2011;43:399-400.
Díaz-Gallo LM, Espino-Paisan L, Fransen K, Gómez-Garcia M, van Sommeren S, Cardeña C, Rodrigo L, Mendoza JL, Taxonera C, Nieto A, Alcain G, Cueto I, López-Nevot MA, Bottini N, Barclay ML, Crusius JBA, van Bodegraven AA, Wijmenga C, Ponsioen CY, Gearry RB, Roberts RL, Weersma RK, Urcelay E, Merriman TR, Alizadeh BZ, Martin J.

Differential association of two PTPN22 coding variants with Crohn´s disease and ulcerative colitis.

Inflammatory Bowel Diseases 2011;17(11):2287-94
Nijmeijer RM, Gadaleta RM, van Mil SWC, van Bodegraven AA, Crusius JBA, Dijkstra G, Hommes DW, de Jong DJ, Stokkers PCF, Verspaget HW, Weersma RK, van der Woude CJ, Stapelbroek JM, Schipper MEI, Wijmenga C, van Erpecum KJ, Oldenburg B on behalf of the Dutch Initiative on Crohn and Colitis (ICC).

Farnesoid X Receptor (FXR) activation and FXR genetic variation in inflammatory bowel disease.

PLoS ONE 2011;6(8): e23745. doi:10.1371/journal.pone.0023745
Peña AS.

Short- and long-term complications after restorative proctocolectomy with ileal pouch-anal anastomosis. (Editorial).

Annals of Gastroenterology 2011;24:161-163
Ksiadzyna D and Peña AS.

Abdominal Splenosis.

Rev Esp Enferm Diges 2011;103(8):421-426
Sombekke MH, van der Voort LF, Kragt JJ, Nielsen JM, Guzel H, Visser A, Oudejans CBM, Crusius JBA, Peña AS, Vrenken H, Polman CH, Killestein J.

Relevance of IL7R genotype and mRNA expression in Dutch patients with multiple sclerosis.

Multiple Sclerosis 2011;17(8):922-30. doi:10.1177/1352458511402411
Vosslamber S, van der Voort LF, van den Elskamp IJ, Heijmans R, Aubin C, Uitdehaag BMJ, Crusius JBA, van der Pouwkraan TCTM, Comabella M, Montalban X, Hafler DA, De Jager PL, Killestein J, Polman CH, Verweij CL.

Interferon regulatory factor 5 gene variants and pharmacological and clinical outcome of Interferon beta therapy in multiple sclerosis.

Genes Immun. 2011;12(6):466-472; doi:10.1038/gene.2011.18
Quint KD, Bom RJ; Quint WG, Bruisten SM, van der Loeff MFS, Morré SA, de Vries HJ.

Anal infections with concomitant Chlamydia trachomatis genotypes among men who have sex with men in Amsterdam, the Netherlands.

BMC infectious diseases 2011;11:63-69
Sombekke MH, Vellinga MM, Uitdehaag BMJ, Barkhof F, Polman CH, Arteta D, Tejedor D, Martinez A, Crusius JBA, Peña AS, Geurts JJG, Vrenken H.

Genetic correlations of brain lesion distribution in Multiple Sclerosis – an exploratory study.

Am J Neuroradiol. 2011;32:695-703.
Quint KD, Geraets DT, van den Munckhof HAM, de Koning MNC, Smelov V, Melchers WJG, de Vries HJC, Morré SA, Meijer CJM, van Alewijk DCJG , van Doorn LJ, Quint WHV.

Evaluation of a novel Chlamydia trachomatis Microsphere Suspension assay for detection and genotyping of the different serovars in clinical samples.

J Mol Diagn 2011;13:152-159.
Sanders MS, van Well GThJ, Ouburg S, Lundberg PSJ, van Furth AM, Morré SA.

Single nucleotide polymorphisms in TLR9 are highly associated with susceptibility to bacterial meningitis in children.

Clin Infect Dis 2011;52:475-80.
Karimi O and Peña AS.

Probiotics in Clinical Practice as Therapeutics against Enteric Disorders. Chapter 15. In: Book

JJ Malago, JFJG Koninkx and R Marinsek-Logar Editors Publisher Springer-Science + Business Media B.V. 2011;355-373.
Roberts RL, Hollis-Moffatt JE, Gomez-Garcia M, Fransen K, Ponsioen CY, Crusius JBA, Wijmenga C, Martin J, Weersma RK, Merriman TR, Barclay ML, Gearry RB, Alizadeh BZ.

Association of the protein-tyrosine phosphatase nonreceptor type substrate 1 (PTPNS1) gene with inflammatory bowel disease.

Inflammatory Bowel Diseases 2011;17:E19-21.
Bartelds GM, de Groot E, Nurmohamed MT, Hart MHL, van Eede PH, Wijbrandts CA, Crusius JBA, Dijkmans BAC, Tak PP, Aarden L, Wolbink GJ.

Surprising negative association between IgG1 allotype disparity and anti-adalimumab formation: a cohort study.

Arthritis Research & Therapy 2010;12(6):R221.
van Dommelen L, van Tiel FH, Ouburg S, Brouwers EEHG, Terporten PHW, Savelkoul PHM, Morre SA, Bruggeman CA,Hoebe CJPA.

Alarmingly poor performance in Chlamydia trachomatis point-of-care testing.

Sex Transm Infect (STI) 2010;86(5):355-9.
Quint KD, Bom RJM, Bruisten SM, van Doorn LJ, Nassir Hajipour N, Melchers WJG, de Vries HJC, Morre SA, Quint WGV.

Comparison of three genotyping methods to identify Chlamydia trachomatis genotypes in positive men and women.

Mol Cel Probes 2010; 24(5): 266-270
Christerson L, de Vries HJC, de Barbeyrac B, Gaydos CA, Henrich B, Hoffmann S, Schachter J, Thorvaldsen J, Vall-Mayans M, Klint M, Herrmann B, Morre SA.

Typing of lymphogranuloma venereum Chlamydia trachomatis strains.

Emerg Infect Dis 2010; 16(11):1777-9
de Vries HJC, Morre SA, White JA, Moi H.

European Guideline for the Management of Lymphogranuloma Venereum, 2010.

International Journal of STD & AIDS 2010; 21(8):533-6
Barreiro-de Acosta M, Ouburg S, Morre SA, Crusius JBA,Lorenzo A, Potel J, Pena AS, Enrique Dominguez-Munoz J.

NOD2, CD14 and TLR4 mutations do not influence response to adalimumab in patients with Crohn’s disease: A preliminary report.

Rev Esp Enferm Digest 2010; 102(10):591-5.
Pena AS

Medicina Personalizada: inevitable. Personalized Medicine: inevitable.

Rev Enferm Dig 2010;102(10):573-576 (Spanish and English)
Fransen K, Visschedijk MC, van Sommeren S, Fu JY, Franke L, Festen EAM, Stokkers PCF, van Bodegraven AA, Crusius JBA, Hommes DW, Zanen P, de Jong DJ, Wijmenga C, van Diemen CC, Weersma RK.

Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn’s disease.

Human Molecular Genetics 2010;19(17):3482-8.
Wu J, Xia B, von Blomberg BME, Zhao C, Yang XW, Crusius JBA, Pena AS.

Coeliac Disease in China, a Field Waiting for Exploration.

Rev Esp Enferm Diges 2010;102(8):472-7
de Vries HJC, Smelov V, Ouburg S, Pleijster J, Geskus RB, Speksnijder AGCL, Fennema JS, Morre SA

Anal lymphogranuloma venereum infection screening with IgA anti-C. trachomatis-specific Major Outer Membrane protein serology.

Sexually transmitted diseases 2010;37(12):789-95
Pena AS and Hadithi M

Antibody testing in coeliac disease.

Eur J Intern Med 2010;21:Letter to the Editor http://dx.doi.org/10.1016/j.ejim.2010.06.011
Cui J, Saevarsdottir S, Thomson B, Padyukov L, van der Helm-van Mil AHM, Nititham J, Hughes LB, de Vries N, Raychaudhuri S, Alfredsson L, Askling J, Wedren S, Ding B, Guiducci C, Wolbink GJ, Crusius JBA, van der Horst-Bruinsma IE, Herenius M, Weinblatt ME, Shadick NA, Worthington J, Batliwalla F, Kern M, Morgan AW, Wilson AG, Isaacs JD, Hyrich K, Seldin MF, Moreland LW, Behrens TW, Allaart CF, Criswell LA, Huizinga TWJ, Tak PP, Bridges SL, Jr., Toes REM, Barton A, Klareskog L, Gregersen PK, Karlson EW, Plenge RM.

Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.

Arthritis & Rheumatism 2010;62(7):1849-61.
Ursum J, van der Weijden MAC, van Schaardenburg D, Prins APA, Dijkmans BAC, Twisk JWR, Crusius JBA, van der Horst-Bruinsma, IE

IL10 GGC haplotype is positively and HLA-DQA1*05-DQB1*02 is negatively associated with radiographic progression in undifferentiated arthritis.

J Rheumatol 2010; 37(7):1431-8. | doi:10.3899/jrheum.090913
Weersma RK, Crusius JBA, Roberts RL, Palomino-Morales R, Koeleman BPC, Wolfkamp S, Hollis-Moffatt JE, Festen EAM, Meisner S, Heijmans R, Noble CL, Gearry RB, Barclay ML, Gomez-Garcia M, Lopez-Nevot MA, Nieto A, Rodrigo L, Radstake TRDJ, van Bodegraven AA, Wijmenga C, Merriman TR, Stokkers PCF, Pena AS, Martin J, Alizadeh BZ.

The Association of FcgR2a, but not FcgR3a, with Inflammatory Bowel Diseases Across Three Caucasian Populations.

Inflammatory Bowel Diseases 2010; 16(12):2080-9 | DOI 10.1002/ibd.21342
Koutroubakis IE and Pena AS

Disease activity and venous thromboembolism in inflammatory bowel disease.

The Lancet 2010,375 Correspondence Page 1689
Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FAS, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, BIRAC Consortium, Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJH, Costenbader KH, Criswell LA, Crusius JBA, Cui J, de Bakker PIW, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TWJ, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TRDJ, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AHM, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PLCM, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, YEAR Consortium, Wijmenga C, Karlson EW, Toes REM, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM.

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.

Nature Genetics 2010;42(6):508-14 | doi:10.1038/ng.582
Sombekke MH, Arteta D, van de Wiel MA, Crusius JBA, Tejedor D,Killestein J, Martinez A, Pena AS, Polman CH, Uitdehaag BMJ

Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis.

Multiple Sclerosis 2010; 16(6):652-9.
Land JA, Van Bergen JEAM, Morre SA, Postma MJ.

Epidemiology of Chlamydia trachomatis infection in women and the cost-effectiveness of screening.

Human Reproduction Update 2010;16(2):189-204
Wu J, Xia B, von Blomberg BME, Zhao C, Yang XW, Crusius JBA, Pena AS

Coeliac disease: emerging in China?

Letter to the Editor GUT 2010, Mar;59(3):418-9
Hadithi M and Pena AS

Current methods to diagnose the unresponsive and complicated forms of coeliac disease.

Eur J Intern Med 2010;21:247-253
Festen EAM, Stokkers PC, van Diemen CC, van Bodegraven AA, Boezen M, Crusius JBA, Hommes DW, van der Woude CJ, Balschun T, Verspaget HW, Schreiber S, de Jong DJ, Franke A, Dijkstra G, Wijmenga C, Weersma RK.

Genetic analysis in a Dutch study sample identifies more ulcerative colitis susceptibility loci and shows their additive role in disease risk.

Am J Gastroenterol 2010;105(2):395-402
Shrestha UK, Karimi O, Crusius JBA, Zhou F, Wang Z, Chen Z, van Bodegraven AA, Xiao J, Morre SA, Wang H, Li J, Xia B.

Distribution of peroxisome proliferator-activated receptor-gamma polymorphisms in Chinese and Dutch patients with inflammatory bowel disease.

Inflammatory bowel diseases 2010;16(2):312-9.
van der Horst-Bruinsma IE, Crusius JBA

New insights in understanding the pathogenesis of spondyloarthropathies (Editorial)

Editorial
Dean D, Bruno WJ, Wan R, Gomes JP, Devignot S, Mehari T, de Vries HJ,Morré SAM, Myers G, Read TD, Spratt BG.

Predicting phenotype and emerging strains among Chlamydia trachomatis infections.

Emerg Infect Dis 2009;15(9):1385-94
Rabasseda X, Morré SA, Ouburg S.

Bioinformatic approaches to the study of Chlamydial diseases.

Drugs Today (Barc) 2009 Nov;45 Suppl B:173-87.
Verweij SP, Bax CJ, Quint KD, Quint WGV, van Leeuwen AP, Peters RPH, Oostvogel PM, Mutsaers JA, Dörr PJ, Pleijster J, Ouburg S, Morré SA.

Significantly higher serologic responses of Chlamydia trachomatis B group serovars versus C and I serogroups.

Drugs Today (Barc) 2009 Nov;45 Suppl B:135-40
Lyons JM, Morré SA, Land JA.

Aspects of reproductive biology that influence the distribution and spread of Chlamydia trachomatis within the female genital tract: a new paradigm.

Drugs Today (Barc) 2009 Nov;45 Suppl B:119-24.
Peña AS, Karimi O, Crusius JBA.

A new avenue to investigate: the autophagic process. From Crohn’s disease to Chlamydia.

Drugs Today (Barc) 2009 Nov;45 Suppl B:113-7
Wang W, Stassen FR, Surcel HM, Öhman H, Tiitinen A, Paavonen J, de Vries HJC, Heijmans R, Pleijster J, Morré SA, Ouburg S.

Analyses of polymorphisms in the inflammasome-associated NLRP3 and miRNA-146A genes in the susceptibility to and tubal pathology of Chlamydia trachomatis infection.

Drugs Today (Barc) 2009 Nov;45 Suppl B:95-103.
Ouburg S, Lyons JM, Land JA, den Hartog JE, Fennema JSA, de Vries HJC, Bruggeman CA, Ito JI, Peña AS, Lundberg PSJ, Morré SA.

TLR9 KO mice, haplotypes and CPG indices in Chlamydia trachomatis infection.

Drugs Today (Barc) 2009 Nov;45 Suppl B:83-93.
den Hartog JE, Lyons JM, Ouburg S, Fennema JSA, de Vries HJC, Bruggeman CA, Ito JI, Peña AS, Land JA, Morré SA.

TLR4 in Chlamydia trachomatis infections: knockout mice, STD patients and women with tubal factor subfertility.

Drugs Today (Barc) 2009 Nov;45 Suppl B:75-82.
Karimi O, Ouburg S, de Vries HJC, Peña AS, Pleijster J, Land JA, Morré SA.

TLR2 haplotypes in the susceptibility to and severity of Chlamydia trachomatis infections in Dutch women.

Drugs Today (Barc) 2009 Nov;45 Suppl B:67-74.
Lyons JM, Igietseme JU, Black CM, Morré SA.

Identification of candidate genes using the murine model of female genital tract infection with Chlamydia trachomatis.

Drugs Today (Barc) 2009 Nov;45 Suppl B:51-9.
Smelov V, Quint KD, Pleijster J, Savelkoul PHM, Shalepo K, Shipitsyna E, Domeika M, Gorelov A, Savicheva A, Quint WGV, de Vries HJC, Ouburg S, Morré SA.

Chlamydia trachomatis serovar distributions in Russian men and women: a comparison with Dutch serovar distributions.

Drugs Today (Barc) 2009 Nov;45 Suppl B:33-8.
Lyons JM, Ouburg S, Morré SA.

An integrated approach to Chlamydia trachomatis infection: the ICTI Consortium, an update.

Drugs Today (Barc) 2009 Nov;45 Suppl B:15-23.
Morré SA, Ouburg S, Peña AS, Brand A.

The EU FP6 EpiGenChlamydia Consortium: contribution of molecular epidemiology and host-pathogen genomics to understanding Chlamydia trachomatis-related disease.

Drugs Today (Barc) 2009 Nov;45 Suppl B:7-13.
Morré SA, Peña AS.

An integrated approach to the understanding of Chlamydia infections: Introduction to the 2009 update.

Drugs Today (Barc) 2009 Nov;45 Suppl B:3-5.
de Vries HS, Plantinga TS, van Krieken JH, Stienstra R, van Bodegraven AA, Festen EAM, Weersma RK, Crusius JBA, Linskens RK, Joosten LAB, Netea MG, de Jong DJ.

Genetic association analysis of the functional c.714T>G polymorphism and mucosal expression of dectin-1 in inflammatory bowel disease.

PloS ONE 2009;4(11):e7818.
Sombekke MH, Lukas C, Crusius JBA, Tejedor D, Killestein J, Arteta D, Martínez A, Uitdehaag BMJ, Knol DL, Peña AS, Geurts JJG, De Jager PL, Barkhof F, Vrenken H, Polman CH.

HLA-DRB1*1501 and spinal cord MRI lesions in Multiple Sclerosis.

Arch Neurol 2009;66:1531-36.
Raychaudhuri S, Thomson BP, Remmers EF, Eyre S, Hinks A, Guiducci C, Catanese JJ, Xie G, Stahl EA, Chen R, Alfredsson L, Amos CI, Ardlie KG, Barton A, Bowes J, Burtt NP, Chang M, Coblyn J, Costenbader KH, Criswell LA, Crusius JB, Cui J, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Kurreeman FA, Lee AT, Liu X, Li Y, Martin P, Morgan AW, Padyukov L, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth P, Altshuler D, Karlson EW, Toes RE, de Vries N, Begovich AB, Siminovitch KA, Worthington J, Klareskog L, Gregersen PK, Daly MJ, Plenge RM

Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.

Nat Genet 2009; 41:1313-8.
Bartelds GM, Wijbrandts CA, Nurmohamed MT, Wolbink GJ, de Vries N, Tak PP, Dijkmans BA, Crusius JBA, van der Horst- Bruinsma IE.

Anti-adalimumab antibodies in rheumatoid arthritis patients are associated with interleukin-10 gene polymorphisms

Arthritis Rheum 2009;60:2541-2.
van Winsen LML, Manenschijn L, van Rossum EFC, Crusius JBA, Koper JW, Polman CH, Uitdehaag BMJ.

A glucocorticoid receptor gene haplotype (TthIII1/ER22/23EK/9beta) is associated with a more aggressive disease course in multiple sclerosis.

J Clin Endocrinol Metabol 2009; 94:2110-14.
Morre SA, Karimi O, Ouburg S.

Chlamydia trachomatis: identification of susceptibility markers for ocular and sexually transmitted infection by immunogenetics.

FEMS Immunol Med Microbiol 2009;55:140-53.
Ferwerda B, Ferwerda G, Plantinga TS, Willment JA, van Spriel AB, Venselaar H, Elbers CC, Johnson MD, Cambi A, Huysamen C, Jacobs L, Jansen T, Verheijen K, Masthoff L, Morre SA, Vriend G, Williams DL, Perfect JR, Joosten LA, Wijmenga C, van der Meer JW, Adema GJ, Kullberg BJ, Brown GD, Netea MG.

Human dectin-1 deficiency and mucocutaneous fungal infections.

N Engl J Med 2009;361(18):1760-7.
Nicu EA, Laine ML, Morre SA, Van der Velden U, Loos BG.

Soluble CD14 in periodontitis.

Innate Immun 2009;15:121-8.
de Vries HJ, Smelov V, Middelburg JG, Pleijster J, Speksnijder AG, Morre SA.

Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment.

Clin Infect Dis 2009;48:53-6.
Weersma RK, Stokkers PC, van Bodegraven AA, van Hogezand RA, Verspaget HW, de Jong DJ, van der Woude CJ, Oldenburg B, Linskens RK, Festen EA, van der Steege G, Hommes DW, Crusius JB, Wijmenga C, Nolte IM, Dijkstra G.

Molecular prediction of disease risk and severity in a large Dutch Crohn’s disease cohort.

Gut 2009;58:388-95.
Hadithi M, Mulder CJJ, Stam F, Azizi J, Crusius JBA, Peña AS, Stehouwer CDA, Smulders YM.

Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.

World J Gastroenterol 2009;15:955-60.
Peña AS

¿Dónde están nuestros conocimientos sobre la genetic de la enfermedad inflamatoria crónica intestinal (EICC)?

Enfermedad Inflamatoria intestinal al día (publicación de Geteccu para formación continuada) 2009;8:3-14
Morre SA, Ouburg S, van Agtmael MA, de Vries HJ.

Lymphogranuloma venereum diagnostics: from culture to real-time quadriplex polymerase chain reaction.

Sex Transm Infect. 2008;84:252-3.
Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP, Gianniny L, Korman BD, Padyukov L, Kurreeman FAS, Chang M, Catanese JJ, Ding B, Wong S, van der Helm-van Mil AHM, Neale BM, Coblyn J, Cui J, Tak PP, Wolbink GJ, Crusius JBA, van der Horst-Bruinsma IE, Criswell LA, Amos CI, Seldin MF, Kastner DL, Ardlie KG, Alfredsson L, Costenbader KH, Altshuler D, Huizinga TWJ, Shadick NA, Weinblatt ME, de Vries N, Worthington J, Seielstad M, Toes REM, Karlson EW, Begovich AB, Klareskog L, Gregersen PK, Daly MJ, Plenge RM.

Common variants at CD40 and other loci confer risk of rheumatoid arthritis.

Nat Genet. 2008;40:1216-23.
Crusius JBA, Canzian F, Capellá G, Peña AS, Pera G, Sala N, Agudo A, Rico F, Del Giudice G, Palli D, Plebani M, Boeing H, Bueno-de-Mesquita HB, Carneiro F, Pala V, Save VE, Vineis P, Tumino R, Panico S, Berglund G, Manjer J, Stenling R, Hallmans G, Martínez C, Dorronsoro M, Barricarte A, Navarro C, Quirós JR, Allen N, Key TJ, Binghan S, Caldas C, Linseisen J, Kaaks R, Overvad K, Tjønneland A, Büchner FC, Peeters PHM, Numans ME, Clavel-Chapelon F, Trichopoulou A, Lund E, Jenab M, Rinaldi S, Ferrari P, Riboli E, González CA.

Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST).

Ann Oncol 2008;19:1894-902.
Karimi O, Crusius JBA, Coucoutsi C, Heijmans R, Sambuelli AM, Peña AS, Koutroubakis IE

JAK2 V617F mutation is not involved in thromboembolism in IBD

Inflammatory Bowel Disease 2008;14:1606-7.
Zhernakova A, Festen EM, Franke L, Trynka G, van Diemen CC, Monsuur AJ, Bevova M, Nijmeijer RM, van ’t Slot R, Heijmans R, Boezen HM, van Heel DA, van Bodegraven AA, Stokkers PCF, Wijmenga C, Crusius JBA, Weersma RK.

Genetic analysis of innate immunity in Crohn’s disease and ulcerative colitis identifies two susceptibility loci harboring CARD9 and IL18RAP

Amer J Hum Gen 2008;82:1202-10.
De Soet JJ, van Gemert-Schriks MC, Laine ML, van Amerongen WE, Morre SA, van Winkelhoff AJ.

Host and microbial factors related to dental caries development.

Caries Res. 2008;42:340-7.
Khorvash F, Keshteli A H, Salehi H, Szeredi L, Morre S A.

Unusual transmission route of Lymphogranuloma venereum;following sexual contact with a female donkey

Int J STD AIDS 2008;19:563-4.
Kupreishvili K, ter Weeme M, Morre SA, van den Brule AJ, Huybregts MA, Quax PH, ter Velden J, Van Hinsbergh VW, Stooker W, Eijsman L, Niessen HW.

Increased infiltration of Clamydophila pneumoniae in the vessel wall of human veins after perfusion

Eur J Clin Invest 2008;38:462-8.
Pannekoek Y, Morelli G, Kusecek B, Morre SA, Ossewaarde JM, Langerak AA, van der Ende A.

Multi locus sequence typing of Chlamydiales: clonal groupings within the obligate intracellular bacteria Chlamydia trachomatis.

BMC Microbiol 2008;8:42
Monsuur AJ, de Bakker PIW, Zhernakova A, Pinto D, Verduijn W, Romanos J, Auricchio R, Lopez A, van Heel DA, Crusius JBA, Wijmenga C.

Effective detection of Human Leukocyte Antigen risk alleles in celiac disease using tag single nucleotide polymorphisms.

PLoS ONE 2008;3:e2270.
Bos WH, Ursum J, de Vries N, Bartelds GM, Wolbink GJ, Nurmohamed MT, van der Horst-Bruinsma IE, van de Stadt RJ, Crusius JBA, Tak PP, Dijkmans BAC, van Schaardenburg DJ.

The role of the shared epitope in arthralgia with anti-cyclic citrullinated peptide antibodies (anti-CCP), and its effect on anti-CCP levels.

Ann Rheum Dis 2008;67:1347-50.
Hadithi M, Cazemier M, Meijer GA, Bloemena E, Felt-Bersma RJ, Mulder CJJ, Meuwissen SGM, Peña AS, van Bodegraven AA.

Retrospective analysis of old age colitis in Dutch IBD population.

World J Gastroenterol 2008;14:3183-3187
Guijarro LG, Mate J, Gisbert JP, Perez-Calle JL, Marín-JimenezI, Arriaza E, Olleros T, Delgado M, Castillejo MS, Prieto-Merino D, Gonzalez-Lara V, Peña AS.

N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized, placebo-controlled pilot study

World J Gastroenterol 2008;14:2851-7
de Vries HJC, van der Bij AK, Fennema JS, Smit C, de Wolf F, Prins M, Coutinho RA, Morré SA.

Lymphogranuloma Venereum Proctitis in Men Who Have Sex With Men Is Associated With Anal Enema Use and High-Risk Behavior.

Sex Transm Dis 2008;35:203-208.
Smelov V, Morre SA, de Vries HJC.

Are serological chlamydia-specific markers useful to detect asymptomatic cases of lymphogranuloma venereum proctitis?

Sex Transm Infect 2008;84:77-8
Perez-Calle JL, Marin-Jimenez I, Lopez-Serrano P, Gisbert JP, Peña AS, Fernandez-Rodriguez C.

Prevalence of macrocreatinkinase type 1 in patients with inflammatory bowel disease.

Dig Dis Sci 2008;53:486-9
Bernardo D, van Hoogstraten IM, Verbeek WH, Peña AS, Mearin ML, Arranz E, Garrote JA, Scheper RJ, Schreurs MW, Bontkes HJ, Mulder CJJ, von Blomberg BM.

Decreased circulating iNKT cell numbers in refractory coeliac disease.

Clin Immunol 2008;126:172–179
Jenab M, McKay JD, Ferrari P, Biessy C, Laing S, Capella Munar GM, Sala N, Peña S, Crusius JBA, Overvad Jensen MK, Olsen A, et al

CDH1 Gene Polymorphisms, Smoking, Helicobacter pylori Infection and the Risk of Gastric Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST)

Eur J Cancer 2008;44:774-80
Karimi O and Peña AS

Indications and Challenges of Probiotics, Prebiotics, and Synbiotics in the Management of Arthralgias and Spondyloarthropathies in Inflammatory Bowel Disease

J Clin Gastroenterol 2008; 42 Supplement 3, Part 1:S136-S141.
Peña AS

Why Are Genetic Studies Important in IBD?

Inflamm Bowel Dis 2008;14:
Peña AS

Intestinal Flora, Probiotics, Prebiotics, Synbiotics and Novel Foods.

Rev Esp Enferm Dig (Madrid) 2007;99:653-658
Peña AS

The significance of CARD15 mutations in Crohn’s disease. The Spanish contribution

Rev Esp Enferm Dig (Madrid) 2007;99:563-569
den Hartog JE, Morre SA, Land JA.

Chlamydia trachomatis en tubapathologie. Welke serummarkers en immunogenetische variabelen zijn zinvol bij screening?

Nederlands Tijdschrift voor Obstetrie en Gynaecologie 2007;120:7-13
Quint KD, van Doorn LJ, Kleter B, de Koning MN, van den Munckhof HA, Morré SA, ter Harmsel B, Weiderpass E, Harbers G, Melchers WJ, Quint WG.

A highly sensitive, multiplex broad-spectrum PCR-DNA-Enzyme immuno assay and reverse hybridization assay for rapid detection and identification of Chlamydia trachomatis serovars

J Mol Diagn 2007;9:631-8.
Lam TJ, Wong BC, Mulder CJ, Pena AS, Hui WM, Lam SK, Chan AO.

Increasing prevalence of advanced colonic polyps in young patients undergoing colonoscopy in a referral academic hospital in Hong Kong.

World J Gastroenterol 2007;13:3873-7.
Catsburg A, van Dommelen L, Smelov V, de Vries HJC, , Savitcheva A, Domeika M, Herrmann B, Ouburg S, Hoebe CJPA, Nilsson A, Savelkoul PHM, Morré SA.

TaqMan Assay for Swedish Chlamydia trachomatis Variant.

Emerg Infect Dis 2007;13:1432-1434
Hadithi M, von Blomberg BM, Crusius JB, Bloemena E, Kostense PJ, Meyer JW, Mulder CJ, Stehouwer CD, Peña AS.

Accuracy of serologic tests and HLA-DQ typing for diagnosing celiac disease.

Ann Intern Med 2007;147:294-302.
Catsburg A, van der Zwet WC, Morre SA, Vandenbroucke-Grauls CM, Savelkoul PH.

Analysis of multiple Single Nucleotide Polymorphisms (SNP) on DNA traces from plasma and dried blood samples.

J. Immunol Methods 2007;321:135-41.
de Vries HJC, Catsburg A ,Beukelaar EC, van der Helm J, Morre SA, Fennema JSA , Thiesbrummel H

No indication of Swedish Chlamydia trachomatis varianta among STI clinic visitors in Amsterdam

Euro Surveil 2007;12: E070208 3
Barreiro-Acosta M, Peña AS

Clinical Applications of NOD2/CARD15 mutations in Crohn’s Disease

Acta Gastroenterológica Latinoamericana 2007; 37:49-54
Mendoza JL, Urçelay E, Lana R, Martin MC, López N, Guijarro LG, Mayol JA, Taxonera C, de la Concha EG, Peña AS, Diaz-Rubio M.

MDR1 polymorphisms and response to azathioprine therapy in patients with Crohn’s disease

Inflamm Bowel Dis 2007;13:585-90.
Barreiro-de Acosta M, Domýnguez-Munoz JE, Nunez-Pardo de Vera MC, Lozano-Leon A, Lorenzo A, Pena AS

Relationship between clinical features of Crohn’s disease and the risk of developing extraintestinal manifestations

Eur J Gastroenterol Hepatol 2007;19:73-8
van der Linde K, Boor PP, Houwing-Duistermaat JJ, Crusius JBA, Wilson Pj, Kuipers EJ, de Rooij FW.

CARD15 mutations in Dutch familial and sporadic inflammatory bowel disease and an overview of European studies.

Eur J Gastroenterol Hepatol 2007;19: 449-459.
Hadithi M, de Boer H, Meijer JW, Willekens F, Kerckhaert JA, Heijmans R, Pena AS, Stehouwer CD, Mulder CJ.

Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa.

World J Gastroenterol 2007;13:1715-1722
Vanrompay D, Lyons JM, Morré SA.

Animal models for the study of Chlamydia trachomatis infections in the female genital infection.

Drugs of Today 2006; 42 (Suppl A): pp. 55 – 63.
van der Graaf CAA, Mihai G. Netea, Morré SA, Den Heijer M, Verweij PE, van der Meer JWM, Kullberg BJ.

Toll-like receptor 4 Asp299Gly/Thr399Ile polymorphisms are a risk factor for Candida bloodstream infection.

European Cytokine Network 2006; 17 (1): pp. 29 – 34.
van der Bij AK, Spaargaren J, Morré SA, Fennema HSA, Mindel A, Coutinho RA, de Vries HJC.

Diagnostic and clinical implications of anorectal lymphogranuloma venereum in men who have sex with men: a retrospective case-control study.

Clinical Infectious Diseases 2006; 42 (2): pp. 186 – 194.
van der Bij AK, Spaargaren J, Morré SA, Fennema HSA, Mindel A, Coutinho RA, de Vries HJC.

Diagnostic and clinical implications of anorectal lymphogranuloma venereum in men who have sex with men: a retrospective case-control study.

Clinical Infectious Diseases 2006; 42 (2): pp. 186 – 194.
Van Bodegraven AA, Curley CR, Hunt KA, Monsuur AJ, Linskens RK, Onnie CM, Crusius JBA, Annese V, Latiano A, Silverberg MS, Bitton A, Fisher SA, Steinhart AH, Forbes A, Sanderson J, Prescott NJ, Strachan DP, Playford RJ, Mathew CG, Wijmenga C, Daly MJ, Rioux JD, Van Heel DA.

Genetic Variation in Myosin IXB Is Associated With Ulcerative Colitis.

Gastroenterology. 2006 Dec;131(6):1768-74.
Vainas T, Stassen FRM, Bruggeman CA, Welten RJT, van den Akker LHJM, Kitslaar PJEH, Peña AS , Morré SA.

Synergistic effect of Toll-like receptor 4 and CD14 polymorphisms on the total atherosclerosis burden in patients with peripheral arterial disease.

Journal of Vascular Surgery 2006; 44 (2): pp. 326 – 332
Peña AS.

Contribution of genetics to a new vision in the understanding of inflammatory bowel disease.

World Journal of Gastroenterology 2006; 12 (30): pp. 4784 – 4787.
Morré SA, Spaargaren J, Ossewaarde JM, Land JA, Bax CJ, Dörr PJ, Oostvogel PM, Vanrompay D, Savelkoul PHM, Pannekoek Y, van Bergen JEAM, Fennema HSA, de Vries HJC, Crusius JBA, Peña AS, Ito JI, Lyons JM.

Description of the ICTI consortium: an integrated approach to the study of Chlamydia trachomatis infection.

Drugs of Today 2006; 42 (Suppl A): pp. 107 – 114.
Morré SA, Spaargaren J, Veldhuijzen IK, Postma MJ, van Bergen JEAM & On behalf of the PILOT CT study-group.

Evaluation of the leukocyte esterase test (LET) as pre-screening test to reduce costs for national population-based Chlamydia trachomatis screening programs.

Journal of Adolescent Health 2006; 38 (4): pp. 332 – 333.
Morré SA, Pannekoek Y, Ossewaarde JM.

More than 25 years of urogenital Chlamydia trachomatis research in the Netherlands.

Drugs of Today 2006; 42 Suppl A pp. 5 – 24.
Marin-Jimenez I, Peña AS.

Budesonide for ulcerative colitis.

Rev. Esp. Enferm. Dig. 2006; 98 (5): pp. 362 – 373.
Lyons JM, Ito JI, Morré SA.

Efficacy of an Immune Modulator in Experimental Chlamydia trachomatis Infection of the Female Genital Tract.

Infect. Dis. Obstet. Gynecol. 2006; 14 (2): pp. 61265.
Laine ML, Leonhardt A, Roos-Jansaker AM, Peña AS, van Winkelhoff AJ, Winkel EG, Renvert S

IL-1RN gene polymorphism is associated with peri-implantitis.

Clin. Oral Implants. Res. 2006; 17 (4): pp. 380 – 385.
Gorter AC, Segura ZE, Savelkoul PHM, Morré SA.

Chlamydia trachomatis infections in Nicaragua: preliminary results from a competitive voucher scheme to prevent and treat sexually transmitted infections and HIV/AIDS among sex workers.

Drugs of Today 2006; 42 Suppl A pp. 47 – 54
Fidder HH, Heijmans R, Chowers Y, Bar-Meir S, Avidan B, Peña AS, Crusius JBA.

TNF-857 polymorphism in Israeli Jewish patients with inflammatory bowel disease

International Journal of Immunogenetics 2006; 33 (2): pp. 81 – 85.
den Hartog JE, Ouburg S, Land JA, Lyons JM, Ito JI, Peña AS ,Morré SA. Do host genetic traits in the bacterial sensing system play a role in t

Do host genetic traits in the bacterial sensing system play a role in the development of Chlamydia trachomatis-associated tubal pathology in subfertile women?

BMC Infectious Diseases 2006; 6 (1): pp. 122.
den Hartog JE, Morré SA, Land JA.

Chlamydia trachomatis-associated tubal factor subfertility: immunogenetic aspects and serological screening.

Hum. Reprod. Update. 2006; 12 (6): pp. 719 – 730.
Al-Toma A, Goerres MS, Meijer JWR, Peña AS, Crusius JBA, Mulder CJJ .

Human leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma.

Clin. Gastroenterol. Hepatol. 2006; 4 (3): pp. 315 – 319.
Lyons JM, Morré SA, Airo-Brown LP, Peña AS, Ito JI.

Acquired homotypic and heterotypic immunity against oculogenital Chlamydia trachomatis serovars following female genital tract infection in mice.

BMC Infectious Diseases 2005; 5(1):105
Vanrompay D, Hoang TQT, De Vos L, Verminnen K, Chiers K, Morré SA, Cox E.

Specific pathogen free pigs as an animal model for studying Chlamydia trachomatis genital infection

Infection and Immunity 2005; 73(12):8317-21.
Lammers KM, Ouburg S, Morré SA, Crusius JBA, Gionchetti P, Rizzello F, Morselli C, Caramelli E, Conte R, Poggioli G, Campieri M, Peña AS.

Combined carriership of TLR9 –1237C and CD14 –260T alleles enhances the risk of developing chronic relapsing pouchitis

World Journal of Gastroenterology 2005; 11(46):7323-9.
Spaargaren J, Schachter J, Moncado J, Fennema HSA, de Vries HJC, Coutinho RA, Morré SA.

Slow Epidemic of Lymphogranuloma Venereum L2b Strain.

Emerging Infect Dis 2005; 11(11):1787-8.
Lyons JM, Morré SA, Airo-Brown LP, Peña AS, Ito JI Jr.

Comparison of multiple genital tract infections with Chlamydia trachomatis in different strains of female mice.

J Microbiol Immunol Infect 2005; 38(6):383-93.
Cox DG, Crusius JB, Peeters PH, Bueno-de-Mesquita HB, Pena AS, Canzian F.

A haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease.

World J Gastroenterol 2005;11:6003-8.
Silverberg MS, Satsangi J, Ahmad T, Arnott ID, Bernstein CN, Brant SR, Caprilli R, Colombel JF, Gasche C, Geboes K, Jewell DP, Karban A, Loftus Jr EV, Peña AS, Riddell RH, Sachar DB, Schreiber S, Steinhart AH, Targan SR, Vermeire S, Warren BF.

Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.

Can J Gastroenterol 2005;19 Suppl A:5-36.
Sander Ouburga,b, J. Bart A. Crusiusb, Elly C. Klinkenberg-Knola, Chris J.J. Muldera, A. Salvador Pen˜aa,b and Servaas A. Morre´ b

A candidate gene approach of immune mediators effecting the susceptibility to and severity of upper gastrointestinal tract diseases in relation to Helicobacter pylori and Epstein–Barr virus infections

European Journal of Gastroenterology & Hepatology 2005, 17:1213–1224
M. Barreiro, C. Núñez1, J. E. Domínguez-Muñoz, A. Lorenzo, F. Barreiro2, J. Potel2 and A. S. Peña1,3

Association of NOD2/CARD15 mutations with previous surgical procedures in Crohn’s disease

REV ESP ENFERM DIG (Madrid) Vol. 97. N.° 8, pp. 547-553, 2005
M. Barreiro, C. Núñez1, J. E. Domínguez-Muñoz, A. Lorenzo, F. Barreiro2, J. Potel2 and A. S. Peña1,3

Association of NOD2/CARD15 mutations with previous surgical procedures in Crohn’s disease

REV ESP ENFERM DIG (Madrid) Vol. 97. N.° 8, pp. 547-553, 2005
O. Karimi and A. S. Peña

Probiotics in arthralgia and spondyloarthropathies in patients with inflammatory bowel disease. Prospective randomized trials are necessary

REV ESP ENFERM DIG (Madrid) Vol. 97. N.° 8, pp. 570-574, 2005
Drugs of Today 2005, 41 (7): 453-459

PROBIOTICS (VSL#3) IN ARTHRALGIA IN PATIENTS WITH ULCERATIVE COLITIS AND CROHN’S DISEASE: A PILOT STUDY

Ouafae Karimi1, A. Salvador Peña1,2 and Adriaan A. van Bodegraven2
M.L. Laine, S.A. Morré, L.S. Murillo, A.-J. van Winkelhoff and A.S. Peña

CD14 and TLR4 Gene Polymorphisms in Adult Periodontitis

J DENT RES 2005 84: 1042
Servaas A. Morre,*^ Joke Spaargaren,t^ Johannes S.A. Fennema,t Henry J.C. de Vries.ft Roel A. Coutinho,t§ and A. Salvador Pena*

Real-time Polymerase Chain Reaction To Diagnose Lymphogranuloma Venereum

Emerging Infectious Diseases • Vol. 11, No. 8, August 2005
M. L. Moreno . J. B. A. Crusius . A. Cherñavsky . E. Sugai . A. Sambuelli . H. Vazquez . E. Mauriño . A. S. Peña . J. C. Bai

The IL-1 gene family and bone involvement in celiac disease

Immunogenetics (2005) 57: 618–620 DOI 10.1007/s00251-005-0033-x
Barr, ourburg, Morre, Igietseme, Okwandu, Francis Eko, Ifere. Belay, He, Lyn, Nwankwo, Lillard, Black, Ananaba

Host inflammatory response and development of complications of Chlamydia trachomatis genital infection in CCR5-deficient mice and subfertile women with the CCR5delta32 gene deletion

J Microbiol Immunol Infect 2005; 38:244-254
Hans-Peter Eich a , Guillermo de la Calle b , Carlos Diaz c , Scott Boyer d , A. S. Peña e , Bruno G. Loos e , Peter Ghazal f , Inge Bernstein g and the INFOBIOMED Network

Practical Approaches to the Development of Biomedical Informatics: the INFOBIOMED Network of Excellence

Bioinformatics and Medical Genomics
M. A. Garcia-Gonzalez,* P. H. M. Savelkoul,† R. Benito,‡ S. Santolaria,§ J. B. A. Crusius, A. S. Peña** & A. Lanas*

No allelic variant associations of the IL-1 and TNF gene polymorphisms in the susceptibility to duodenal ulcer disease

2005 Blackwell Publishing Ltd, International Journal of Immunogenetics 32, 299–306
Yvonne Pannekoek,1* Joke Spaargaren,2 Ankie A. J. Langerak,1 Judith Merks,2 Servaas A. Morre´,3 and Arie van der Ende1

Interrelationship between Polymorphisms of incA, Fusogenic Properties of Chlamydia trachomatis Strains, and Clinical Manifestations in Patients in The Netherlands

JOURNAL OF CLINICAL MICROBIOLOGY, May 2005, p. 2441–2443 Vol. 43, No. 5
Joke Spaargaren,* Han S.A. Fennema,* Servaas A. Morre,t Henry J.C. de Vries.t and Roel A. Coutmho§

New Lymphogranuloma Venereum Chlamydia trachomatis Variant, Amsterdam

Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 11. No. 7, July 2005
Juan Shang, AS Peña

Multidisciplinary approach to understand the pathogenesis of gastric cancer

World J Gastroenterol 2005;11(27):4131-4139 World Journal of Gastroenterology ISSN 1007-9327
Q S Guo, B Xia, Y Jiang, S A Morre´, L Cheng, J Li, J B A Crusius, A S Peña

Polymorphisms of CD14 gene and TLR4 gene are not associated with ulcerative colitis in Chinese patients

Postgrad Med J 2005;81:526–529. doi: 10.1136/pgmj.2004.030825
M van der Paardt, J B A Crusius, M A Garcia-Gonzalez, B A C Dijkmans, A S Peña, I E van der Horst-Bruinsma

Susceptibility to ankylosing spondylitis: no evidence for the involvement of transforming growth factor b1 (TGFB1) gene polymorphisms

Ann Rheum Dis 2005;64:616–619. doi: 10.1136/ard.2004.027698
JOSEPH M. LYONS1, JAMES I. ITO JR1, SERVAAS A. MORRÉ

The influence of vaginally applied imiquimod on the course of Chlamydia trachomatis serovar D infection in a murine model

Infectious Diseases in Obstetrics and Gynecology, March 2005; 13(1): 1–3
K. van der Linde a, P.P.C. Boor b, A.A. van Bodegraven c, D.J. de Jong d, J.B.A. Crusius e, T.H.J. Naber d, E.J. Kuipers a, J.H.P. Wilson b, F.W.M. de Rooij b, ∗

A functional interleukin-10 mutation in Dutch patients with Crohn’s disease

Digestive and Liver Disease 37 (2005) 330–335
S Ouburg, R Mallant-Hent, J B A Crusius, A A van Bodegraven, C J J Mulder, R Linskens, A S Peña, S A Morre

The toll-like receptor 4 (TLR4) Asp299Gly polymorphism is associated with colonic localisation of Crohn’s disease without a major role for the Saccharomyces cerevisiae mannan-LBP-CD14-TLR4 pathway

doi: 10.1136/gut.2004.054486
J M Lyons, J I Ito Jr, A S Peña, S A Morre

Differences in growth characteristics and elementary body associated cytotoxicity between Chlamydia trachomatis oculogenital serovars D and H and Chlamydia muridarum

J Clin Pathol 2005;58:397–401. doi: 10.1136/jcp.2004.021543
Sander Ouburg†1,2, Joke Spaargaren†3, Janneke E den Hartog4, Jolande A Land4, Johan SA Fennema5, Jolein Pleijster1, A Salvador Peña1, Servaas A Morré*1 and the ICTI consortium

The CD14 functional gene polymorphism -260 C>T is not involved in either the susceptibility to Chlamydia trachomatis infection or the development of tubal pathology

BMC Infectious Diseases 2005, 5:114 doi:10.1186/1471-2334-5-114
Herma Fidder, M.D., Yehuda Chowers, M.D., Zvi Ackerman, M.D., Rivka Dresner Pollak, M.D., J. Bart. A. Crusius, Ph.D., Avi Livneh, M.D., Simon Bar-Meir, M.D., Benjamin Avidan, M.D., and Yael Shinhar, Ph.D.

The Familial Mediterranean Fever (MEVF) Gene as a Modifier of Crohn’s Disease

ISSN 0002-9270 C   2005 by Am. Coll. of Gastroenterology doi: 10.1111/j.1572-0241.2005.40810.x
M van der Paardt, J B A Crusius, M H M T de Koning, S A Morré, R J van de Stadt, B A C Dijkmans, A S Peña, I E van der Horst-Bruinsma

No evidence for involvement of the Toll-like receptor 4 (TLR4) A896G and CD14-C260T polymorphisms in susceptibility to ankylosing spondylitis

Ann Rheum Dis 2005;64:235–238
MICHELLE E. A. BORM,* JIANPING HE,‡ BRIAN KELSALL,‡ A. SALVADOR PEÑA,* WARREN STROBER,§ and GERD BOUMA*,§

A Major Quantitative Trait Locus on Mouse Chromosome 3 Is Involved in Disease Susceptibility in Different Colitis Models

GASTROENTEROLOGY 2005;128:74–85
María A. García-González, Angel Lanas, Jing Wu, Rafael Benito, Santos Santolaria, Bart Crusius, and Salvador Peña

Lack of Association of IL-12 p40 Gene Polymorphism With Peptic Ulcer Disease

Human Immunology 66, 72-76 (2005)
Laura Fernandez, PhD,* Juan L. Mendoza, MD, PhD,† Alfonso Martinez, PhD,* Elena Urcelay, PhD,* Miguel Fernandez-Arquero, PhD,* Julio Garcia-Paredes, MD, PhD,† A. Salvador Peña, MD, PhD,‡ Manuel Diaz-Rubio, MD, PhD,† and Emilio G. de la Concha, MD, PhD*

IBD1 and IBD3 Determine Location of Crohn’s Disease in the Spanish Population

Inflamm Bowel Dis • Volume 10, Number 6, November 2004
J M Lyons, J I Ito Jr, S A Morre

Chlamydia trachomatis serovar E isolates from patients with different clinical manifestations have similar courses of infection in a murine model: host factors as major determinants of C trachomatis mediated pathogenesis

J Clin Pathol 2004;57:657–659. doi: 10.1136/jcp.2003.013086
Bax, Trimbos, Spaargaren, Oostvogel, Peña, Morré

Chlamydia trachomatis heat shock protein 60 (cHSP60) antibodies in women without and with tubal pathology using a new commercially available assay

Sex Transm Infect 2004;80:415–421
A Zwiers1, D Seegers1, R Heijmans1, A Koch2, J Hampe2, S Nikolaus2, AS Pen˜ a1, S Schreiber2 and G Bouma1

Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn’s disease

2004 Nature Publishing Group All rights reserved 1466-4879/04
A Zwiers1, D Seegers1, R Heijmans1, A Koch2, J Hampe2, S Nikolaus2, AS Pen˜ a1, S Schreiber2 and G Bouma1

Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn’s disease

2004 Nature Publishing Group All rights reserved 1466-4879/04
Carlos J. Cara1, Amado Salvador Pena2, Miquel Sans3, Luis Rodrigo4, Mercedes Guerrero-Esteo1, Joaquín Hinojosa5, Julio García-Paredes6, Luis G. Guijarro7

Reviewing the mechanism of action of thiopurine drugs: toward a new paradigm in clinical practice

Med Sci Monit, 2004; 10(10): RA
D Franchimont, S Vermeire, H El Housni, M Pierik, K Van Steen, T Gustot, E Quertinmont, M Abramowicz, A Van Gossum, J Deviere, P Rutgeerts

Deficient host-bacteria interactions in inflammatory bowel disease? The toll-like receptor (TLR)-4 Asp299gly polymorphism is associated with Crohn’s disease and ulcerative colitis

Gut 2004;53:987–992. doi: 10.1136/gut.2003.030205
Kolkman, H. Möllmann, A. Möllmann, Peña, Greinwald, Tauschel, Hochhaus

EVALUATION OF ORAL BUDESONIDE IN THE TREATMENT OF ACTIVE DISTAL ULCERATIVE COLITIS

Drugs of today 2004, 40 (7): 589-601
B Diosdado, M C Wapenaar, L Franke, K J Duran, M J Goerres, M Hadithi, J B A Crusius, J W R Meijer, D J Duggan, C J J Mulder, F C P Holstege, C Wijmenga

A microarray screen for novel candidate genes in coeliac disease pathogenesis

Gut 2004;53:944–951. doi: 10.1136/gut.2003.018374
HANS M. SCHRIJVER,1 J. BART A. CRUSIUS,2 M. ASUN‚ION GARCêA-GONZçLEZ,2,6 CHRIS H. POLMAN,1 A. SALVADOR PE„A,2,3 FREDERIK BARKHOF,4 and BERNARD M.J. UITDEHAAG1,5

Gender-Related Association Between the TGFB11+869 Polymorphism and Multiple Sclerosis

JOURNAL OF INTERFERON & CYTOKINE RESEARCH 24:536-542 (2004)
Bao-Ying Fei, Bing Xia, Chang-Sheng Deng, Xiao-Qing Xia, Min Xie, J Bart A Crusius, A Salvador Pena

Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population

World J Gastroenterol 2004;10(9):1256-1261 Fax: +86-10-85381893 World Journal of Gastroenterology
Monica Molano,1,2 Chris J. L. M. Meijer,1 Servaas A. Morre´,1 Rene Pol,1 and Adriaan J. C. van den Brule1,3*

Combination of PCR Targeting the VD2 of omp1 and Reverse Line Blot Analysis for Typing of Urogenital Chlamydia trachomatis Serovars in Cervical Scrape Specimens

JOURNAL OF CLINICAL MICROBIOLOGY, July 2004, p. 2935–2939 Vol. 42, No. 7
H. M. Schrijver, T. Hooper-van Veen,† M. J. van Belzen,‡ J. B. A. Crusius,§ A. S. Peña,§¶ F. Barkhof, C. H. Polman & B. M. J. Uitdehaag††

Polymorphisms in the genes encoding interferon-γ and interferon-γ receptors in multiple sclerosis

2004 Blackwell Publishing Ltd, European Journal of Immunogenetics 31, 133–140
Immunogenetics

Genomewide Screen in a Four-Generation Dutch falily with celiac disease

ISSN 0002-9270
MJ van Belzen1,2, BPC Koeleman1, JBA Crusius3, JWR Meijer4, AFJ Bardoel1, PL Pearson1, LA Sandkuijl{, RHJ Houwen2 and C Wijmenga1

Defining the contribution of the HLA region to cis DQ2-positive coeliac disease patients

Genes and Immunity (2004) 5, 215–220
Seegers, Peña, Bouma

Het auto-immuun lymfoproliferatief syndroom: een stoornis in de geprogrammeerde celdood

Ned Tijdschr Geneeskd 2004 21 februari;148(8)
J Spaargaren, I Verhaest, S Mooij, C Smit, H S A Fennema, R A Coutinho, A Salvador Peña, S A Morre

Analysis of Chlamydia trachomatis serovar distribution changes in the Netherlands (1986–2002)

Sex Transm Infect 2004;80:151–156
Irene GM van Valkengoed,1,2 Servaas A Morré,3,4 Adriaan JC van den Brule,3,5 Chris JLM Meijer,3 Lex M Bouter1 and A Joan P Boeke1

Overestimation of complication rates in evaluations of Chlamydia trachomatis screening programmes—implications for cost-effectiveness analyses

International Journal of Epidemiology 2004;33:416–425 DOI: 10.1093/ije/dyh029
M. L. Laine1, L. S. Murillo2, S. A. Morre´2, E. G. Winkel3, A. S. Pen˜a2,4 and A. J. van Winkelhoff1

CARD15 gene mutations in periodontitis

J Clin Periodontol 2004; 31: 890–893 doi: 10.1111/j.1600-051X.2004.00577.x
NUÑEZ, BARREIRO, DOMINGUEZ MUÑOZ, LORENZO, ZAPATA, PEÑA

CARD15 Mutations in patients with Crohn’s Disease in a Homogeneous spanish population

ISSN 00002-9270 DOI 10.111/J1572-0241.2004.040666.X
Jing Wu, BZ Alizadeh, TV Veen, JWR Meijer, CJJ Mulder, AS Peña

Association of FAS (TNFRSF6)-670 gene polymorphism with villous atrophy in coeliac disease

World J Gastroenterol 2004;10(5):717-720
A. S. PEÑA, J. J. KOLKMAN, R. GREINWALD, H.-D. TAUSCHEL, F. G. NELIS, P. VIERGEVER, A. C. MÓLLMANN, G. HOCHHAUS and H. W. MÓLLMANN

Pharmacokinetics after single and multiple oral dosing of budesonide pHmodified- release capsules in patients with distal ulcerative colitis

Kluwer Academic Publishers. Dordrecht, Boston 2004;pp 30-35.
R.K. Linskens a,∗,1, R.C. Mallant-Hent a,1, L.S. Murillo b, B.M.E. von Blomberg c, B.Z. Alizadeh d, A.S. Peña a,b

Genetic and serological markers to identify phenotypic subgroups in a Dutch Crohn’s disease population

Digestive and Liver Disease 36 (2004) 29–34
SERVAAS A. MORRÉ, SANDER OUBURG, ELLY C. KLINKENBERG-KNOL, CHRIS J. J. MULDER, A. SALVADOR PEÑA

The True Ligand of the NOD2 Receptor Is Peptidoglycan Instead of Lipopolysaccharide: A Schematic Representation of Ligand-Receptor Interactions and NF-kB Activation

GASTROENTEROLOGY Vol. 126, No. 1
O. Karimi, A.S. Peña

Clinical Aspects of probiotics

Intestinal microflora and Human Health
J. L. Mendoza, L. S. Murillo, L. Fernandez, A. S. Peña, R. Lana, E. Urcelay, D. M. Cruz-Santamaria, E. G. de la Concha, M. Dıaz-Rubio & J. Garcıa-Paredes

Prevalence of Mutations of the NOD2/CARD15 Gene and Relation to Phenotype in Spanish Patients with Crohn Disease

Scand J Gastroenterol 2003 (12)
GONZÁLEZ, PEÑA, CAPELLA

Clinical Usefulness of Virulence Factors of Helicobacter pylori as Predictors of the Outcomes of Infection. What is the Evidence?

Scand J Gastroenterol 2003 (9)
D. Seegers,* M. E. A. Borm,* M. J. van Belzen,† C. J. J. Mulder,* J. Bailing,*§ J. B. A. Crusius,* J. W. R. Meijer,‡ C. Wijmenga,† A. S. Peña* & G. Bouma*

IL12B and IRF1 gene polymorphisms and susceptibility to celiac disease

2003 Blackwell Publishing Ltd, European Journal of Immunogenetics 30, 421–425
KIMURA, HUNTER, MIKAEL, THOLLANDER, EDWARD, LOFTUS, MELTON, PETER, O'BRIEN, RODRIGUEZ, SIDNEY PHILLIPS

Concurrence of inflammatory Bowel Disease and Multiple Sclerosis

Inflammatory Bowel Disease and Multiple Sclerosis, Mayo Clin Proc, August 2000, Vol 75
A. S. Peña

Change and progress in inflammatory bowel disease

REV ESP ENFERM DIG (Madrid) Vol. 95. N.° Extraordinario, pp. 65-67, 2003
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