Immunity and inflammation: Infection

Immunogenetics and environmental factors in infectious diseases.

S.A. Morré1, S. Ouburg1, J. Spaargaren2, R.A. Coutinho2, Y. Pannekoek3, J. Lyons4, J.I. Ito4,  J. Land 5, C. Bruggeman6, M. Laine7, A-J. van Winkelhoff7, P.H. Savelkoul8, C.M.J.EVandenbroucke-Grauls8, M. van Agtmael9, S. Danner9, J.B.A. Crusius1, A.S. Peña1,10

1Laboratory of Immunogenetics, 2GG&GD Amsterdam, 3AMC Medical Microbiology, 4City of Hope National Medical Center, Dept. of Infectious Diseases, Duarte, CA, USA, 5AZM, Dept. Gynecology, 6AZM, Dept of Medical Microbiology, 7Dept. of Basic Dental Sciences, 8Medical Microbiology and Infection Prevention, 9Internal Medicine and 10Gastroenterology, VU University Medical Center (Grants: 1. Medac, 2. Sarphati 3. EC-FP6 NoE INFOBIOMED Contact No. 507585)

The differences in the clinical course of infectious diseases depend on behavioral, environmental, bacterial and host factors. To investigate the contribution of host factors involved in the susceptibility to and severity of infections we follow an integrated approach: 1) a candidate gene approach based on genes involved in innate and acquired immunity, such as NF-kB activation, the IL1 gene family, TNF, Toll-like receptors (2, 4 and 9) and CARD15; 2) murine knockout models 3) genetic-epidemiological approaches 4) bacterial typing. The clinical models comprise: urogenital infections, periodontitis and AIDS in well-defined patient cohorts.

(DI) Murillo LS. The immunogenetics of infectious diseases: a candidate gene approach based on the regulation of NF-kB. VU University Medical Center. Promotor: Prof A.S. Peña, MD, PhD, FRCP. Co-promotor: S.A. Morré, Ph.D. Prous Science: Barcelona, Spain, 2003: 178p. (cat. A).
Debets-Ossenkopp YJ, Reyes G, Mulder J, Aan De Stegge BM, Peters JT, Savelkoul PH, Tanca J, Peña AS, Vandenbroucke-Grauls CM. Characteristics of clinical Helicobacter pylori strains from Ecuador.  J Antimicrob Chemother 2003;51:141-5.

(WI) >Land JA, Pleijster J, Bruggeman CA, Peña AS, Morré SA. Interleukin-1B (IL-1B) and interleukin-1 receptor antagonist (IL-1RN) gene polymorphisms are not associated with tubal pathology and Chlamydia trachomatis-related tubal factor subfertility. Hum Reprod 2003; 18(11): 2309-14.

(WI) Murillo LS, Morré SA, Peña AS. TLR and NOD/CARD proteins: Pattern recognition receptors are key elements in the regulation of the immune response. Drugs Today 2003, 39 (6): 415-438.

(LE) Morré SA, Murillo LS, Bruggeman CA, Peña AS. The Role That the Functional Asp299Gly Polymorphism in the Toll-Like Receptor-4 Gene Plays in the Susceptibility to Chlamydia trachomatis Associated Tubal Infertility. Infect Dis 2003;Jan 15;187:341-343.

(WB) Van Winkelhoff AJ, Laine ML, Peña AS. Genetic and microbial aspects of destructive periodontal disease. In: Tuncer O, Mutlu S, Scully C. Periodontal Tissue Destruction and Remodelling-Quintessence 2003. p. 1-10.